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Atorvastatin genericon 10 -year survival with and without LDL-C/HDL-C ratio, according to primary outcome (primary endpoint). We observed no overall difference between the groups Inderal dosage for essential tremor with regard to primary endpoint, the relative CV risk reduction, mean age at entry and the baseline LDL-C at time of randomization. As expected based on the results of when did atorvastatin become generic primary end points reported herein, the combination of statin therapy with atorvastatin was associated significantly more CV events than did statin therapy with atorvastatin alone. It is not possible to infer from the findings of this study with absolute certainty that the combination of statins and atorvastatin is more effective than either therapy alone in preventing CV events. As the events were independent of all other events, including those related to CV disease, it is difficult to make a firm conclusion regarding the mechanism of action. Future studies are needed to more specifically examine the role played by combination of statins and atorvastatin in preventing CV events. In contrast to the findings of this study, a recent meta-analysis of 8 randomized clinical trials lipid-lowering drugs and CV events revealed no overall difference between statin treatment groups and placebo.21 A previous meta-analysis,22 which involved only 9 randomized trials, also did not reveal an overall benefit of statin therapy with atorvastatin over placebo treatment. Both of these previous meta-analyses relied on the same definition of CV event, defined as major CVD events, but they used different definitions of CV risk reduction. In the current study, primary outcome, rate of CV events, was assessed and defined as the ratio of major CVD events (defined as myocardial infarction [MI], stroke or fatal nonfatal pulmonary embolism) to a composite of events included in the definition of CV disease (defined as myocardial infarction, stroke, nonfatal infarction or fatal stroke). In contrast, according to the definition used in previous meta-analysis, the only CVD outcomes that were counted in this meta-analysis those included the definition of CV risk reduction. Both these definitions included major CV events. Both of these meta-analyses relied on the same method of analysis data (i.e., a random effects model) and the same definitions for outcomes (i.e., the definition was based on rate of major CVD events). Therefore, it can be concluded that neither of these two large meta-analyses statin therapy, which reported conflicting results, provides firm evidence regarding the CV benefits of statins. atorvastatin generic coupons Nevertheless, the findings this present study support the findings reported in recent meta-analytic review23 of 11 randomized clinical trials statin therapy and CV events, in which the authors reported that there was no difference in the CV risk reduction of statin therapy alone compared with atorvastatin. Both of the studies included in this review, including the studies of meta-analysis by Bélanger et al.23 and the meta-analysis by Bélanger et al.23 were conducted by the same investigators. The authors believe that there are several reasons why the results of this study cannot be applied to the treatment of patients with CV disease: a) receiving statin therapy alone may have an increased atorvastatin 40 mg coupons risk of CV events in the first 3 months of treatment; b) in most studies, the definition of CV risk in the definition of CV event is not specified; c) in other studies, the definition of CV risk reduction is based on the CV events defined by Stokes et al.24; d) the use of statins for 3 months is not a long-term therapy, because statin therapy Atorvastatin 10mg $54.46 - $0.45 Per pill is prescribed for a period of 3 months to decrease LDL-C; and e) there are insufficient data to evaluate the effect of long-term statin therapy at the population level. It has been reported that long-term statin therapy reduces CV events in patients with mild-to-moderate CHD.25–27 the current study, in contrast to the results of a meta-analysis effects statin therapy alone and combined treatment (statins plus atorvastatin), duration and dose were not controlled in the current study. In conclusion, this was the first study that systematically compared the effects of statin therapy with atorvastatin or without LDL-C/HDL-C ratio on CV events in patients with known cardiovascular disease. The results suggest that treatment of patients with atorvastatin and/or plus LDL-C/HDL-C ratio is associated with a higher CV risk reduction than treatment with statin therapy alone. Further studies are needed to specifically characterize the role played by combination of statins and atorvastatin in preventing CV events to provide a better understanding of CV benefits and.



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